27肌醇烟酸酯片15% 47源和VSMC我关键值P发生在2000 caoce是什么东西啊

来源：蜘蛛抓取(WebSpider) 时间：2017-03-27 19:42 标签： 2 氯烟酸
The effects of exogenous fatty acids and niacin on human monocyte-macrophage plasticity. - Abstract - Europe PMC
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Sergio Montserrat-de la Paz
Laboratory of Cellular and Molecular Nutrition, Instituto de la Grasa, CSIC. Ctra. de Utrera Km. 1, 41013, Seville, Spain.
Dolores Rodriguez
Laboratory of Cellular and Molecular Nutrition, Instituto de la Grasa, CSIC. Ctra. de Utrera Km. 1, 41013, Seville, Spain.
Magdalena P Cardelo
Laboratory of Cellular and Molecular Nutrition, Instituto de la Grasa, CSIC. Ctra. de Utrera Km. 1, 41013, Seville, Spain.
Maria C Naranjo
Laboratory of Cellular and Molecular Nutrition, Instituto de la Grasa, CSIC. Ctra. de Utrera Km. 1, 41013, Seville, Spain.
Beatriz Bermudez
Department of Cell Biology, School of Biology, University of Seville, C/ Profesor Garcia Gonzalez s/n, 41012, Seville, Spain.
Rocio Abia
Laboratory of Cellular and Molecular Nutrition, Instituto de la Grasa, CSIC. Ctra. de Utrera Km. 1, 41013, Seville, Spain.
Francisco J G Muriana
Laboratory of Cellular and Molecular Nutrition, Instituto de la Grasa, CSIC. Ctra. de Utrera Km. 1, 41013, Seville, Spain.
Sergio Lopez
Laboratory of Cellular and Molecular Nutrition, Instituto de la Grasa, CSIC. Ctra. de Utrera Km. 1, 41013, Seville, Spain.
Laboratory of Cellular and Molecular Nutrition, Instituto de la Grasa, CSIC. Ctra. de Utrera Km. 1, 41013, Seville, Spain.
Department of Cell Biology, School of Biology, University of Seville, C/ Profesor Garcia Gonzalez s/n, 41012, Seville, Spain.
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Macrophage plasticity allows adapting to different environments, having a dual activity in inflammatory-related diseases. Our hypothesis is that the type of dietary fatty acids into human postprandial triglyceride-rich lipoproteins (TRLs), alone or in combination with niacin (vitamin B3), could modulate the plasticity of monocytes-macrophages.We isolated TRLs at the postprandial peak from blood samples of healthy volunteers after the ingestion of a meal rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) or MUFAs plus omega-3 long-chain polyunsaturated fatty acids (LCPUFAs). Autologous monocytes isolated at fasting were first induced to differentiate into na&ve macrophages. We observed that postprandial TRL-MUFAs, particularly in combination with niacin, enhance competence to monocytes to differentiate and polarise into M2 macrophages. Postprandial TRL-SFAs made polarised macrophages prone to an M1 phenotype. In contrast to dietary SFAs, dietary MUFAs in the meals plus immediate-release niacin primed circulating monocytes for a reduced postprandial pro-inflammatory profile.Our study underlines a role of postprandial TRLs as a metabolic entity in regulating the plasticity of the monocyte-macrophage lineage and also brings an understanding of the mechanisms by which dietary fatty acids are environmental factors fostering the innate immune responsiveness in humans. This article is protected by copyright. All rights reserved.
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CitePeer Related ArticlesEffect of acetoacetate on biosynthesis of niacin in vitro. - Abstract - Europe PMC
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(PMID:5798613)
Shastri NV
[):130-131]
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