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Hidden-Action in Multi-Hop Routing
&&Abstract C In any multi-hop routing scheme, cooperation by the intermediate nodes are essential for the succesful delivery of traffic. However, the effort exerted by the intermediate nodes are often unobservable by the source and/or destination nodes. We
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ensearchwebFrom Wikipedia, the free encyclopedia
Identifiers
, HEL-S-94n, HOP, IEF-SSP-3521, P60, STI1, STI1L, stress induced phosphoprotein 1
External IDs
Gene location (Human)
64,185,272
64,204,543
Gene location (Mouse)
Chromosome 19 (mouse)
Molecular function
Cellular component
Biological process
Sources: /
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
Hop, occasionally written HOP, is an abbreviation for - Organizing Protein. It functions as a co-chaperone which reversibly links together the protein
Hsp70 and Hsp90.
Hop belongs to the large group of , which regulate and assist the major
(mainly ). It is one of the best studied co-chaperones of the Hsp70/Hsp90-complex. It was first discovered in
were identified in human, mouse, rat, insects, plants, parasites, and virus. The family of these proteins is referred to as STI1 (stress inducible protein) and can be divided into yeast, plant, and animal STI1 (Hop).
Hsc70/Hsp90-organizing protein
NY-REN-11 antigen
Transformation-sensitive protein IEF-SSP-3521
The gene for human Hop is located on 13.1 and consists of 14 .
STI proteins are characterized by some structural features: All homologues have nine tetratricopeptide repeat (TPR) motifs, that are clustered into domains of three TPRs. The TPR motif is a very common structural feature used by many proteins and provides the ability of directing protein-protein interactions.
structural information is available for the
TPR1 and the central TPR2A domains in complex with Hsp90 resp. Hsp70
The Hsp70-Hsp90 Organizing Protein (Hop, STIP1 in humans) is the co-chaperone responsible for the transfer of client proteins between Hsp70 and Hsp90. Hop is evolutionarily conserved in Eukaryotes and is found in both the nucleus and cytoplasm. Drosophila Hop is a monomeric protein that consists of three tetratricopeptide repeat domain regions (TPR1, TPR2A, TPR2B), one aspartic acid-proline repeat domain (DP). The TPR domains interact with the c-terminals of Hsp90 and Hsp70, with TPR1 and TPR2B binding to Hsp70 and TPR2A binding preferentially to Hsp90. The intermediate structures of heat shock machinery are difficult to characterize completely because of the transient and fast paced nature of chaperone function.
The main function of Hop is to link
together. But recent investigations indicate that it also modulates the chaperone activities of the linked proteins and possibly interacts with other chaperones and proteins. Apart from its role in the Hsp70/Hsp90 "chaperone machine" it seems to participate in other protein complexes too (for example in the
complex EcR/USP and in the
complex, which enables the viral replication). It acts as a receptor for
proteins too. Hop is located in diverse cellular regions and also moves between the
In Drosophila
pathways, Hop has been shown to be an integral part of the pre-RISC complex for . In the Drosophila
pathway, the RNA interference pathway responsible for the repression of transposable elements (transposons), Hop has been shown to interact with Piwi, and in the absence of Hop, transposons are derepressed, leading to severe genomic instability and infertility.
Human Hop (STIP1) has been shown to
- , May 2017
- , May 2017
Odunuga OO, Longshaw VM, Blatch GL (October 2004). "Hop: more than an Hsp70/Hsp90 adaptor protein". BioEssays. 26 (10): 1058–68. :.  .
Scheufler C, Brinker A, Bourenkov G, Pegoraro S, Moroder L, Bartunik H, Hartl FU, Moarefi I (April 2000). "Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine". Cell. 101 (2): 199–210. :.  .
Schmid AB, et al. (2012). "The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop". EMBO J. 31: 1506–17. :.
Yamamoto S, et al. (2014). "ATPase activity and ATP-dependent conformational change in the co-chaperone HSP70/HSP90-organizing protein (HOP)". J. Biol. Chem. 289: 9880–6. :.
Martins VR, Graner E, Garcia-Abreu J, de Souza SJ, Mercadante AF, Veiga SS, Zanata SM, Neto VM, Brentani RR (December 1997). "Complementary hydropathy identifies a cellular prion protein receptor". Nature Medicine. 3 (12): 1376–82. :.  .
Zanata SM, Lopes MH, Mercadante AF, Hajj GN, Chiarini LB, Nomizo R, Freitas AR, Cabral AL, Lee KS, Juliano MA, de Oliveira E, Jachieri SG, Burlingame A, Huang L, Linden R, Brentani RR, Martins VR (July 2002). . The EMBO Journal. 21 (13): 3307–16. :.   .  .
Iwasaki S, Sasaki HM, Sakaguchi Y, Suzuki T, Tadakuma H, Tomari Y (May 2015). "Defining fundamental steps in the assembly of the Drosophila RNAi enzyme complex". Nature. 521 (7553): 533–6. :.  .
Gangaraju VK, Yin H, Weiner MM, Wang J, Huang XA, Lin H (February 2011). . Nature Genetics. 43 (2): 153–8. :.   .  .
Karam JA, Parikh RY, Nayak D, Rosenkranz D, Gangaraju VK (April 2017). . The Journal of Biological Chemistry. 292 (15): . :.   .  .
Zanata SM, Lopes MH, Mercadante AF, Hajj GN, Chiarini LB, Nomizo R, Freitas AR, Cabral AL, Lee KS, Juliano MA, de Oliveira E, Jachieri SG, Burlingame A, Huang L, Linden R, Brentani RR, Martins VR (July 2002). . The EMBO Journal. 21 (13): 3307–16. :.   .  .
Scheufler C, Brinker A, Bourenkov G, Pegoraro S, Moroder L, Bartunik H, Hartl FU, Moarefi I (April 2000). "Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine". Cell. 101 (2): 199–210. :.  .
Johnson BD, Schumacher RJ, Ross ED, Toft DO (February 1998). "Hop modulates Hsp70/Hsp90 interactions in protein folding". The Journal of Biological Chemistry. 273 (6): 3679–86. :.  .
Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J (December 1992). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. :.  .
Honoré B, Leffers H, Madsen P, Rasmussen HH, Vandekerckhove J, Celis JE (April 1992). "Molecular cloning and expression of a transformation-sensitive human protein containing the TPR motif and sharing identity to the stress-inducible yeast protein STI1". The Journal of Biological Chemistry. 267 (12): 8485–91.  .
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. :.  .
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. :.  .
Dittmar KD, Pratt WB (May 1997). "Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation". The Journal of Biological Chemistry. 272 (20): 13047–54. :.  .
Dittmar KD, Demady DR, Stancato LF, Krishna P, Pratt WB (August 1997). "Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. The role of p23 is to stabilize receptor.hsp90 heterocomplexes formed by hsp90.p60.hsp70". The Journal of Biological Chemistry. 272 (34): 21213–20. :.  .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. :.  .
Zou J, Guo Y, Guettouche T, Smith DF, Voellmy R (August 1998). "Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1". Cell. 94 (4): 471–80. :.  .
Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, J?ger D, J?ger E, Knuth A, Chen YT, Old LJ (November 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. 83 (4): 456–64. :.  .
Scheufler C, Brinker A, Bourenkov G, Pegoraro S, Moroder L, Bartunik H, Hartl FU, Moarefi I (April 2000). "Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine". Cell. 101 (2): 199–210. :.  .
Hernández MP, Chadli A, Toft DO (April 2002). "HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor". The Journal of Biological Chemistry. 277 (14): 11873–81. :.  .
Brinker A, Scheufler C, Von Der Mulbe F, Fleckenstein B, Herrmann C, Jung G, Moarefi I, Hartl FU (May 2002). "Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexes". The Journal of Biological Chemistry. 277 (22): 19265–75. :.  .
Zanata SM, Lopes MH, Mercadante AF, Hajj GN, Chiarini LB, Nomizo R, Freitas AR, Cabral AL, Lee KS, Juliano MA, de Oliveira E, Jachieri SG, Burlingame A, Huang L, Linden R, Brentani RR, Martins VR (July 2002). . The EMBO Journal. 21 (13): 3307–16. :.   .  .
Hernández MP, Sullivan WP, Toft DO (October 2002). "The assembly and intermolecular properties of the hsp70-Hop-hsp90 molecular chaperone complex". The Journal of Biological Chemistry. 277 (41): 3. :.  .
Abbas-Terki T, Briand PA, Donzé O, Picard D (September 2002). "The Hsp90 co-chaperones Cdc37 and Sti1 interact physically and genetically". Biological Chemistry. 383 (9): 1335–42. :.  .
Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R (December 2003). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". The Journal of Biological Chemistry. 278 (51): 51901–10. :.  .
Longshaw VM, Chapple JP, Balda MS, Cheetham ME, Blatch GL (February 2004). "Nuclear translocation of the Hsp70/Hsp90 organizing protein mSTI1 is regulated by cell cycle kinases". Journal of Cell Science. 117 (Pt 5): 701–10. :.  .
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. :.  .
PDB gallery
1elr: Crystal structure of the TPR2A domain of HOP in complex with the HSP90 peptide MEEVD 
1elw: Crystal structure of the TPR1 domain of HOP in complex with a HSC70 peptide & 488,751 Results
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