为什么www55coco失效了，怎么找55coco的com现在地止_百度知道
为什么www55coco失效了，怎么找55coco的com现在地止
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早就换过去了，应该是以前的那站现在防屏蔽了所以才换的
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关闭关闭关闭Protein knowledgebaseSequence archiveHelp pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects.Sequence clustersProtein sets from fully sequenced genomesAnnotation systemsSystems used to automatically annotate proteins with high accuracy:Supporting dataSelect one of the options below to target your search:You are using a version of browser that may not display all the features of this website. Please consider upgrading .
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Cytochrome P450 3A43CYP3A43Homo sapiens (Human)-Annotation score: -Experimental evidence at protein leveliFunctioniExhibits low testosterone 6-beta-hydroxylase activity.MiscellaneousChimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A4 or CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. CYP3A43-CYP3A4 chimeric transcripts exist in 3 different combinations: CYP3A43 exon 1 joined in frame to CYP3A4 exons 2-13, CYP3A43 exon 1 joined in frame to CYP3A4 exons 4-13 and CYP3A43 exon 1 joined in frame to CYP3A4 exon 7-13. The longest chimeric isoform (CYP3A43 exon 1 joined to CYP3A4 exons 2-13) exhibits 6-beta-hydroxylase activity, while a shorter isoform (CYP3A43 exon 1 joined to CYP3A4 exons 4-13) does not. CYP3A43-CYP3A5 chimeric transcripts exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver (PubMed:).Manual assertion inferred by curator fromi"Intergenic mRNA molecules resulting from trans-splicing.",
[] [] []Cited for: TRANS-SPLICING.Catalytic activityiRH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.CofactoriSitesFeature keyPosition(s)DescriptionActionsGraphical viewLengthMetal bindingiIron (heme axial ligand)1GO - Molecular functioniKeywordsiMolecular function, Ligand, , Enzyme and pathway databasesReactomei Miscellaneous substrates.
Xenobiotics. Names & TaxonomyiProtein namesiRecommended name:Cytochrome P450 3A43 (EC:)Gene namesiName:OrganismiTaxonomic identifieri
[]Taxonomic lineagei >
Proteomesi Componenti: Chromosome 7 Organism-specific databasesEuPathDBi HGNCi CYP3A43. MIMi gene. neXtProti Subcellular locationi
Extracellular region or secreted
Plasma membrane
Cytoskeleton
Peroxisome
Golgi apparatus
Mitochondrion
Manual annotation
Automatic computational assertionGraphics by Christian S Source: Keywords - Cellular componenti, , Pathology & BiotechiOrganism-specific databasesDisGeNETi OpenTargetsi PharmGKBi Chemistry databasesChEMBLi DrugBanki Cobimetinib.
Daclatasvir.
Dexamethasone.
Dolutegravir.
Ethosuximide.
Netupitant.
Phenelzine.
Praziquantel.
Rifampicin.
Rifapentine.
Testosterone.
Troleandomycin.
Zalcitabine. Polymorphism and mutation databasesBioMutai DMDMi PTM / ProcessingiMolecule processingFeature keyPosition(s)DescriptionActionsGraphical viewLengthChainiPRO_Cytochrome P450 3A43 503Proteomic databasesPaxDbi PeptideAtlasi PRIDEi PTM databasesiPTMneti PhosphoSitePlusi ExpressioniTissue specificityiHighest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle.Manual assertion based on experiment ini"cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450.", , , Mol. Pharmacol. 59:386-392(2001)
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, CHARACTERIZATION."Cloning and tissue distribution of a novel human cytochrome P450 of the CYP3A subfamily, CYP3A43.", , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.InductioniBy rifampicin.Gene expression databasesBgeei CleanExi ExpressionAtlasi baseline and differential. Genevisiblei HS. Organism-specific databasesHPAi
InteractioniProtein-protein interaction databasesSTRINGi Chemistry databasesBindingDBi Structurei3D structure databasesProteinModelPortali SMRi ModBaseiMobiDBiFamily & DomainsiSequence similaritiesiBelongs to the .Phylogenomic databaseseggNOGi Eukaryota.
LUCA. GeneTreei HOGENOMi HOVERGENi InParanoidi KOi OMAi OrthoDBi PhylomeDBi TreeFami Family and domain databasesGene3Di 1 hit. InterProi Cyt_P450.
Cyt_P450_CS.
Cyt_P450_E_CYP3A.
Cyt_P450_E_grp-II.
Cyt_P450_sf. Pfami p450. 1 hit. PRINTSi EP450II.
EP450IICYP3A.
P450. SUPFAMi SSF48264. 1 hit. PROSITEi CYTOCHROME_P450. 1 hit. Sequences (5)iSequence statusi: Complete.This entry describes 5 isoformsi produced by alternative splicing. Note: Additional isoforms seem to exist. (identifier: Q9HB55-1)
[]This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
50MDLIPNFAME TWVLVATSLV LLYIYGTHSH KLFKKLGIPG PTPLPFLGTI
100LFYLRGLWNF DRECNEKYGE MWGLYEGQQP MLVIMDPDMI KTVLVKECYS
150VFTNQMPLGP MGFLKSALSF AEDEEWKRIR TLLSPAFTSV KFKEMVPIIS
200QCGDMLVRSL RQEAENSKSI NLKDFFGAYT MDVITGTLFG VNLDSLNNPQ
250DPFLKNMKKL LKLDFLDPFL LLISLFPFLT PVFEALNIGL FPKDVTHFLK
300NSIERMKESR LKDKQKHRVD FFQQMIDSQN SKETKSHKAL SDLELVAQSI
350IIIFAAYDTT STTLPFIMYE LATHPDVQQK LQEEIDAVLP NKAPVTYDAL
400VQMEYLDMVV NETLRLFPVV SRVTRVCKKD IEINGVFIPK GLAVMVPIYA
450LHHDPKYWTE PEKFCPERFS KKNKDSIDLY RYIPFGAGPR NCIGMRFALT
500NIKLAVIRAL QNFSFKPCKE TQIPLKLDNL PILQPEKPIV LKVHLRDGIT SGP
50357,670March 1, 2001 - v1Checksum:i2C585B9DC573F634BLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutter (identifier: Q9HB55-2)
[]The sequence of this isoform differs from the canonical sequence as follows:
: E → ES>>50457,757Checksum:iCB87C6873DAB7B0DBLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutter (identifier: Q9HB55-3)
[]The sequence of this isoform differs from the canonical sequence as follows:
: FS → SH
: Missing.>>42048,304Checksum:iBA207BLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutter (identifier: Q9HB55-4)
[]The sequence of this isoform differs from the canonical sequence as follows:
: SLFPFLTPVFEALNIGLFPKDVTHFLK → YRVSLCCLGRSAWCDLGSLKPPPPGFE
: Missing.Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.>>25028,490Checksum:i7A06BLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutter (identifier: Q9HB55-6)
[]The sequence of this isoform differs from the canonical sequence as follows:
: GLWNFDRECN...FLDPFLLLIS → RSLNKIPSWA...VMKNTEKCGA>>39344,808Checksum:iA0D1FE1BLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutterPolymorphismiAt protein level, three alleles are known: CYP3A43*1, CYP3A43*2 and CYP3A43*3. The sequence shown is that of CYP3A43*1, which is the most frequent allele. The allele CYP3A43*2 is likely to be non-functional.Natural variantFeature keyPosition(s)DescriptionActionsGraphical viewLengthNatural variantiVAR_018050YGTHS…IMDPD → LGPIHINFLRSWEFLGQPLC LFWELFCSTLGVFGILTENV MKNTEKCGGCMRGNSPCWSS WIPT in allele CYP3A43*2.
64Natural variantiVAR_048449. Corresponds to variant .1Natural variantiVAR_018051Missing
in allele CYP3A43*2.
415Natural variantiVAR_048450. Corresponds to variant .1Natural variantiVAR_048451. Corresponds to variant .1Natural variantiVAR_018052 in allele CYP3A43*3. Manual assertion based on experiment ini"First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant.", , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CYP3A43*2), VARIANT CYP3A43*3 ALA-340.Corresponds to variant .1Alternative sequenceFeature keyPosition(s)DescriptionActionsGraphical viewLengthAlternative sequenceiVSP_056736GLWNF…LLLIS → RSLNKIPSWAWWLTPVIPAL WEAEAGGSPKVRSSRPALPT WVFGILTENVMKNTEKCGA in isoform . Manual assertion based on opinion ini"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7). 169Alternative sequenceiVSP_000612SLFPF…THFLK → YRVSLCCLGRSAWCDLGSLK PPPPGFE in isoform .
27Alternative sequenceiVSP_000613Missing
in isoform .
253Alternative sequenceiVSP_000609E → ES in isoform . 1Alternative sequenceiVSP_000610FS → SH in isoform . 2Alternative sequenceiVSP_000611Missing
in isoform .
83Sequence databasesSelect the link destinations:EMBLiGenBankiDDBJi mRNA. Translation: . mRNA. Translation: . Genomic DNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . Genomic DNA. Translation: . Genomic DNA. Translation: . Genomic DNA. Translation: . Genomic DNA. Translation: . mRNA. Translation: .CCDSi
[]PIRi RefSeqi
[]UniGenei Genome annotation databasesEnsembli; ; .
[]GeneIDi KEGGi UCSCi human.
[]Keywords - Coding sequence diversityi, Similar proteinsi mRNA. Translation: . mRNA. Translation: . Genomic DNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . Genomic DNA. Translation: . Genomic DNA. Translation: . Genomic DNA. Translation: . Genomic DNA. Translation: . mRNA. Translation: .CCDSi
[]PIRi RefSeqi
[]UniGenei 3D structure databasesProteinModelPortali SMRi ModBaseiMobiDBiProtein-protein interaction databasesSTRINGi Chemistry databasesBindingDBi ChEMBLi DrugBanki Cobimetinib.
Daclatasvir.
Dexamethasone.
Dolutegravir.
Ethosuximide.
Netupitant.
Phenelzine.
Praziquantel.
Rifampicin.
Rifapentine.
Testosterone.
Troleandomycin.
Zalcitabine. PTM databasesiPTMneti PhosphoSitePlusi Polymorphism and mutation databasesBioMutai DMDMi Proteomic databasesPaxDbi PeptideAtlasi PRIDEi Protocols and materials databasesStructural Biology KnowledgebaseGenome annotation databasesEnsembli; ; .
[]GeneIDi KEGGi UCSCi human.
[]Organism-specific databasesCTDi DisGeNETi EuPathDBi GeneCardsi H-InvDBi HGNCi CYP3A43. HPAi
MIMi gene. neXtProti OpenTargetsi PharmGKBi GenAtlasiPhylogenomic databaseseggNOGi Eukaryota.
LUCA. GeneTreei HOGENOMi HOVERGENi InParanoidi KOi OMAi OrthoDBi PhylomeDBi TreeFami Enzyme and pathway databasesReactomei Miscellaneous substrates.
Xenobiotics. Miscellaneous databasesChiTaRSi human. GeneWikii GenomeRNAii PROi SOURCEiGene expression databasesBgeei CleanExi ExpressionAtlasi baseline and differential. Genevisiblei HS. Family and domain databasesGene3Di 1 hit. InterProi Cyt_P450.
Cyt_P450_CS.
Cyt_P450_E_CYP3A.
Cyt_P450_E_grp-II.
Cyt_P450_sf. Pfami p450. 1 hit. PRINTSi EP450II.
EP450IICYP3A.
P450. SUPFAMi SSF48264. 1 hit. PROSITEi CYTOCHROME_P450. 1 hit. ProtoNeti Q9HB57Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002Last sequence update: March 1, 2001Last modified: March 28, 2018This is version 155 of the entry and version 1 of the sequence. Entry statusiReviewed (UniProtKB/Swiss-Prot)Annotation programDisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.MiscellaneousiKeywords - Technical termi,无论怎么办wWw就是无法联接999dmdm了，什么原因能999dmdm导致不显示com内容_百度知道
无论怎么办wWw就是无法联接999dmdm了，什么原因能999dmdm导致不显示com内容
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你不用找原因的可练接的在这了，999dmdm.6sa.biz
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我们会通过消息、邮箱等方式尽快将举报结果通知您。DMDM Hydantoin(DMDM Hydantion, DMDMH, 1,3-Dimethylol-5,5-dimethylhydantoin)二羥甲基二甲基乙內酰脲, DMDM 乙內醯脲防腐劑，能耐酸性，較適合酸性配方使用[1]。DMDM 為Dimethylol Dimethyl。DMDM Hydantoin 利用釋放甲醛以製造出微生物不適應之環境，藉此達到防腐效果。
屬低度皮膚過敏危險性[2]。[1] 張麗卿，『優質保養品選擇策略』，聯經出版社，。
[2] 台大醫院皮膚部，陳玄祥醫師，註明出自 CosDNA，並提供連結 http://www.cosdna.com 方可引用本資料
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