Pouteria ramiflora (Mart.) Radlk. extract: Flavonoids quantification and chemopreventive effect on HepG2 cells.
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):792-804. doi: 10.4.. Epub
2018 Jul 12.Pouteria ramiflora (Mart.) Radlk. extract: Flavonoids quantification and chemopreventive effect on HepG2 cells.1, 2,3, 1, 1, 1, 3, 4, 5, 6, 1.1a Departamento de Biologia Geral, Centro de Ciências Biológicas , Universidade Estadual de Londrina - UEL , Londrina , Paraná , Brazil.2b Instituto Federal de Educa??o, Ciência e Tecnologia de Mato Grosso - IFMT , Cuiabá , Mato Grosso , Brazil.3c Departamento de Química Org?nica, Instituto de Química , Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP , Araraquara , S?o Paulo , Brazil.4d Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas , Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP , Araraquara , S?o Paulo , Brazil.5e Campus Experimental do Litoral Paulista, Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP , S?o Vicente , S?o Paulo , Brazil.6f Instituto de Investigaciones Biológicas Clemente Estable - IIBCE. Montevideo , Montevideo , Uruguay.AbstractPouteria ramiflora (Mart.) Radlk., popularly known as curriola, is commonly used in Brazil as medicinal plant to treat worm infections, dysentery, pain, inflammation, hyperlipidemia, and obesity. At present the safety of this extract when used therapeutically in human remains to be determined. Thus, the aim of this study was to examine cytotoxicity, antiproliferative, and antimutagenic actions of this extract. The hydroalcoholic extract from P. ramiflora leaves consisted of flavonoids identified and quantified as myricetin-3-O-β-D-galactopyranoside (13.55 mg/g) and myricetin-3-O-α-L-rhamnopyranoside (9.61 mg/g). The extract exhibited cytotoxicity at concentrations higher than 1.5 ug/ml in human hepatocarcinoma (HepG2)and 2.5 ug/ml in non-tumoral primary gastric (GAS) cells using the MTT assay, and at concentrations higher than 3 ug/ml in HepG2 and 3.5 ug/ml in GAS cells by the neutral red assay. The extract did not show antiproliferative effect as evidenced by the nuclear division index (NDI). However, in the presence of benzo[a]pyrene (BaP) (positive control), an enhanced cytostatic effect in the NDI and flow cytometry was noted. It is of interest that when the extract was co-incubated with BaP a significant decrease in DNA damage was observed indicating an antimutagenic action. This protective effect might be attributed to myricetin and gallic acid found in P. ramiflora extract. The low cytotoxicity action and protective effect observed in the present study encourage further studies regarding other biological effects of P. ramiflora, as well as its potential use as a chemopreventive agent.PMID:
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By closing this message, you are consenting to our use of cookies.N,N′-Bis(2-azaniumylbenzyl)ethane-1,2-diaminium tetrachloride
By&Luis &amp, Sylvain Bern&amp, Perla Elizondo Mart&amp, Blanca N&amp and Nancy P&amp
The title compound, C16H26N44+·4Cl−, is based on a fully protonated tetraamine. In the cation, both benzene rings are connected by an all-trans chain, and the rings are almost parallel, with an angle between the mean planes of 8.34 (12)°. The benzene rings are arranged in such a way that the NH3+ substituents are oriented cis with respect to the central chain. This arrangement is a consequence of multiple N—H...Cl hydrogen bonds, involving all N—H groups in the cation and the four independent Cl− anions. These contacts have strengths ranging from weak to strong (based on H...Cl separations), and generate a complex three-dimensional crystal structure with no preferential crystallographic orientation for the contacts
LCC:Chemistry,
LCC:QD1-999,
LCC:Science,
DOAJ:Chemistry (General),
DOAJ:Chemistry
Publisher: International Union of Crystallography
Year: 2011
DOI identifier: 10.
OAI identifier:
oai:doaj.org/article:c431fae0c9
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